The control of the different angiogenic process is an important point in osteochondral regeneration. Angiogenesis is a prerequisite for osteogenesis in vivo; insufficient neovascularization of bone constructs after scaffold implantation resulted in hypoxia and cellular necrosis. Otherwise, angiogenesis must be avoided in chondrogenesis; vascularization of the cartilage contributes to structural damage and pain. Finding a balance between these processes is important to design a successful treatment for osteochondral regeneration. This chapter shows the most important advances in the control of angiogenic process for the treatment of osteochondral diseases focused on the administration of pro- or anti-angiogenic factor and the design of the scaffold.
CITATION STYLE
García-Fernández, L. (2018). Osteochondral angiogenesis and promoted vascularization: New therapeutic target. In Advances in Experimental Medicine and Biology (Vol. 1059, pp. 315–330). Springer New York LLC. https://doi.org/10.1007/978-3-319-76735-2_14
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