α1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis

Abstract

α1 antitrypsin is an important immunoregulatory protein, the serum level of which is genetically determined. Deficient phenotypes of this ubiquitous protease inhibitor are associated with a variety of inflammatory diseases including anterior uveitis. In order to investigate the role of this protease inhibitor in the pathogenesis of retinal vasculitis (RV) 25 patients were investigated. Diseases associated with RV included Behçet's syndrome (8), SLE (2), and sarcoidosis (1). Deficient phenotypes of α1 antitrypsin were not associated with RV. However, the serum α1 antitrypsin level was significantly increased in patients with active RV and paralleled disease activity in patients studied prospectively.