Mastocytosis is characterized by an increase in mast cells in one or more organs and is divided into cutaneous (mast cell accumulation in the skin) and systemic forms (mast cell accumulation in extracutaneous organs). Cutaneous forms usually develop in childhood and take a benign course, whereas the systemic disease tends to occur in adults and is usually chronic. After activation, mast cells release a multitude of different mediators; activation can take place in line with an allergic reaction, but also through physical factors, toxins, hormones or drugs. Manifestations of mastocytosis are caused by the released mediators, but can vary depending on the type of mastocytosis.
CITATION STYLE
Maurer, M., & Siebenhaar, F. (2022). Mastocytoses. In Braun-Falco’s Dermatology (pp. 1965–1972). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-63709-8_111
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