1647 Unlicensed and Off-Label Medication use in the Neonatal Intensive Care Unit: A Prospective Cohort Study

Abstract

Objectives Ureaplasma species were associated bronchopulmonary dysplasia in preterm infants. We aim to analyze the antibiotic susceptibility of ureaplasma urealyticum and clinical manifestations in preterm infants with ureaplasma urealyticum colonization. Methods In a retrospective study, 416 preterm infants ( <0.001). Infants with ureaplasma infection had higher incidence of moderate/ severe BPD. For antimicrobial susceptibility, 23% of erythromycin resistance, 16% of zithromycin resistance, 38% of ciprofloxacin resistance and no jasamycin resistance were shown. Among 31 infants with erythromycin treatment, 18 (58%) of susceptible, 6 (19%) of intermediate were cured after 13 days of treatment, and 4 showed poor response erythromycin treatment, 2 changed to josamycin and 2 infants to clarithromycin and all were completely treated. Conclusion Ureaplasma colonized infants showed higher incidence of BPD. Proper antimicrobial use may reduce the morbidity associated with ureaplasma colonization.