Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents

Abstract

In recent years, application of nanoparticles in different fields of biomedical research, paves its way. Nanosized drugs are claimed to decrease toxicity and reduce the needed dose. Selenium is one of the essential trace element in the body that exhibits both anti-oxidative and pro-oxidative effects and is of great importance for nourishment and medicine. Like other nanoparticles, selenium nanoparticles (SeNPs) possess some unique mechanical, optical, electrical, biologic and chemical properties as compared with bulk materials. The aim of the study was to evaluate the possible effects of orally consumed high doses of SeNPs on rodents' alimentary tract after single (1000 and 5000 mg/ kg) and repeated (500 mg/kg) 90 day administration.