Recent advances in metal-free aerobic C-H activation

Abstract

Herein we describe recent developments in selective, metal-free, dioxygen-induced C-H activation. This method of activating C-H bonds is an attractive alternative to traditional methodologies as it uses dioxygen, an inherently sustainable and widely accessible oxidant, in place of expensive or toxic metals and/or hazardous peroxides. Reactions developed on the basis of using aerobic C-H activation are also discussed.