BOLD dynamic model of functional MRI

Abstract

Blood oxygenation level dependent (BOLD)contrast based functional magnetic resonance imaging (fMRI)can be used to detect brain neural activities. In this paper, a new procedure is presented which allows the estimation of the hemodynamic approach from BOLD responses. The procedure is based on Friston proposed dynamic model and Agnes Aubert proposed a correlation model between activation and motabolism, in this case, adopted to characterize hemodynamic responses in functional magnetic resonance imaging (fMRI). This work represents a fundamental improvement over existing approaches to system identification using nonlinear hemodynamic models. The model can simulate the change of oxygen motabolism, de-oxyhemoglobine, cerebral blood flow and volume to brain activation. © Springer-Verlag Berlin Heidelberg 2007.