The effects of soursop leaves extract on the islets of langerhans of the male wistar rats exposed to high fat diet and streptozotocin

Abstract

The extract of soursop leaves possesses an ability to function as an antioxidant and is potentially capable of being radical scavenging, which allows it to reduce oxidative stress in the pancreatic beta cell and stimulate the endogen regeneration of the islets of Langerhans. This research aimed to analyse the effect of the extract of soursop leaves on the diameters of the islets of Langerhans within the male Wistar rats exposed to high fat diet and streptozotocin. Research design based on the concept of post-test only control group design. The total number of samples in the research was 50 male Wistar rats, consisting of 2 control groups and 3 groups of different dosage treatments of soursop leaves extract. Several findings were discovered, in which there is an effect on the diameters of the islets following the utilization of 150 mg/kg extraction of soursop leaves, and a significant positive correlation between the extract dosage of soursop leaves and the diameters of the islets (r = 0.462;p = 0.005). It can be concluded that the higher the extract dosage is utilized, the more enhancement shown by the diameters of the islets, indicating a rapid cell regeneration performed by the pancreatic beta cell.