Synergism between NF-κB1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes

  • Moran S
  • Cariappa A
  • Liu H
  • et al.
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Abstract

NF-κB1 and Notch2 are both required for the development of marginal zone (MZ) B cells. Analysis of B lymphocyte development in mice that are doubly heterozygous at the Notch2 and NF-κB1 loci revealed synergism between Notch2 and NF-κB1 during MZ B cell development. Two known transcriptional targets of the Notch pathway, Hes-5 and Deltex-1, were found to be preferentially expressed in MZ B cells and regulated by NF-κB1. These studies provide in vivo evidence for a genetic interaction between the Notch and NF-κB pathways.

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Moran, S. T., Cariappa, A., Liu, H., Muir, B., Sgroi, D., Boboila, C., & Pillai, S. (2007). Synergism between NF-κB1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes. The Journal of Immunology, 179(1), 195–200. https://doi.org/10.4049/jimmunol.179.1.195

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