Drugs may have synergistic or antagonistic interactions when combined. Checkerboard assays, where two drugs are combined in many doses, allow sensitive measurement of drug interactions. Here, we describe a protocol to measure the pairwise interactions among three antibiotics, in duplicate, in 5 days, using only two 96-well microplates and standard laboratory equipment.
CITATION STYLE
Cokol-Cakmak, M., & Cokol, M. (2019). Miniaturized checkerboard assays to measure antibiotic interactions. In Methods in Molecular Biology (Vol. 1939, pp. 3–9). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9089-4_1
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