The impact of poly(ADP-ribose) polymerase (PARP) enzymes on cellular NAD+ has been established for almost 30 years now and its sequel, the metabolic collapse of cells upon PARP overactivation is a nearly 20-year-old observation. However, in the last decade there was an enormous blooming in the understanding of the interplay between PARPs and mitochondria. Mitochondrial activity can be assessed by a comprehensive set of methods that we aim to introduce here.
CITATION STYLE
Mikó, E., Kovács, T., Fodor, T., & Bai, P. (2017). Methods to assess the role of poly(ADP-ribose) polymerases in regulating mitochondrial oxidation. In Methods in Molecular Biology (Vol. 1608, pp. 185–200). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6993-7_13
Mendeley helps you to discover research relevant for your work.