Single-cell profiling approaches to probing tumor heterogeneity

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Abstract

Tumor heterogeneity is a major hindrance in cancer classification, diagnosis and treatment. Recent technological advances have begun to reveal the true extent of its heterogeneity. Single-cell analysis (SCA) is emerging as an important approach to detect variations in morphology, genetic or proteomic expression. In this review, we revisit the issue of inter- and intra-tumor heterogeneity, and list various modes of SCA techniques (cell-based, nucleic acid-based, protein-based, metabolite-based and lipid-based) presently used for cancer characterization. We further discuss the advantages of SCA over pooled cell analysis, as well as the limitations of conventional techniques. Emerging trends, such as high-throughput sequencing, are also mentioned as improved means for cancer profiling. Collectively, these applications have the potential for breakthroughs in cancer treatment.

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Khoo, B. L., Chaudhuri, P. K., Ramalingam, N., Tan, D. S. W., Lim, C. T., & Warkiani, M. E. (2016, July 15). Single-cell profiling approaches to probing tumor heterogeneity. International Journal of Cancer. Wiley-Liss Inc. https://doi.org/10.1002/ijc.30006

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