Role of menin in neuroendocrine tumorigenesis

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Abstract

The menin protein encoded by the MENl tumor suppressor gene is ubiquitously expressed and highly conserved evolutionarily. The combination of findings from current in vitro and in vivo studies has not yielded a comprehensive understanding of the mechanisms of menin's tumor suppressor activity or the specific role for menin in endocrine tumorigenesis, alth ough its diverse interactions suggest possible pivotal roles in transcriptional regulation,DNA processing and repa ir and cytoskeleral integrity. This manuscript summarizes recent research findings including studies ofglobal gene expression in MEN I-associated neuroendocrine tumors and pivotal changes in intracellular signaling pathways associated with neuroendocrine tumorigenesis. Finally, the clinical applications provided by the understanding of the effects ofMENl gene mutations on neuroendocrine tumor development in patients with this familial cancer syndrome are discussed. © 2009 Landes Bioscience and Springer Science+Business Media.

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Lairmore, T. C., & Chen, H. (2009). Role of menin in neuroendocrine tumorigenesis. Advances in Experimental Medicine and Biology, 668, 87–95. https://doi.org/10.1007/978-1-4419-1664-8_9

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