Asymptomatic primary hyperparathyroidism

Abstract

Primary hyperparathyroidism (PHPT) is common, with epidemiological studies suggesting it may affect up to 3 % of postmenopausal females. The most common presentation is asymptomatic hypercalcemia. Although surgery is unambiguously recommended for symptomatic PHPT patients, management options for asymptomatic patients can vary between surgery, observation, and follow-up. In cases of asymptomatic PHPT, a thorough evaluation of PHPT-related complications should be performed and patients who do not meet surgical criteria or are unable to proceed with parathyroidectomy should be monitored on an annual basis, since over time, approximately one-third of patients will demonstrate disease progression.