IgG4 levels in bile for distinguishing IgG4-associated cholangiopathy from other biliary disorders: A single blinded pilot study

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Abstract

Background/Aims: Immunoglobulin G4 (IgG4)-associated cholangiopathy (IAC) is an infammatory disease and may mimic primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), or pancreatic cancer on cholangiography. We investigated whether IgG4 levels in bile aspirated during endoscopic retrograde cholangiopancreatography (ERCP) can distinguish IAC from PSC, CCA, and pancreatic cancer. Methods: Bile was aspirated directly from the common bile duct during ERCP in patients with IAC prior to steroid therapy. For control purposes, bile was obtained from patients with PSC, CCA, pancreatic cancer, and benign biliary conditions (sphincter of oddi dysfunc-tion/choledocholithiasis). Conclusions: Te results of this pilot study suggest that measurement of biliary IgG4 levels may have clinical value in distinguishing patients with IAC from biliary disorders that can mimic IAC. Results: Biliary IgG4 levels were measured in 54 patients. Te median bile IgG4 levels were markedly elevated in patients with IAC (5.5 mg/dL; interquartile range [IQR], 5.1 to 15.6) as compared to patients with benign biliary conditions (0 mg/dL; IQR, 0 to 0.1; p=0.003). Te median biliary IgG4 levels in PSC, CCA, and pancreatic cancer were 1.2 (IQR, 0.2 to 3.8), 0.9 (IQR, 0.2 to 3.4), and 0.2 mg/dL (IQR, 0.1 to 0.8), respectively. A cutof value of 3.8 mg/dL distinguished IAC from PSC and CCA patients with 100% and 76.9% sensitivity and specifcity, respectively.

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APA

Navaneethan, U., Gutierrez, N. G., Jegadeesan, R., Venkatesh, P. G. K., Poptic, E., Sanaka, M. R., … Parsi, M. A. (2014). IgG4 levels in bile for distinguishing IgG4-associated cholangiopathy from other biliary disorders: A single blinded pilot study. Clinical Endoscopy, 47(6), 555–559. https://doi.org/10.5946/ce.2014.47.6.555

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