Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo

Citations of this article
Mendeley users who have this article in their library.


Soil-transmitted helminth (STH) infections are responsible for a huge public health burden, however treatment options are limited. The discovery and development of novel efficacious drugs or drug combinations for the treatment of STH infections therefore has a high research priority. We studied drug combination effects using the main standard anthelmintics, albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin in the < em > Trichuris muris < /em > model. Drug combinations were first tested < em > in vitro < /em > and additive and synergistic combinations investigated further < em > in vivo < /em > in female mice using ratios based on the ED < sub > 50 < /sub > of the respective drugs. < em > In vitro < /em > all 10 combinations of the standard anthelmintics tested against < em > T. muris < /em > revealed synergistic behavior. We identified three drug combinations < em > in vivo < /em > as strongly synergistic, namely mebendazole-ivermectin (Combination index (CI)=0.16), mebendazole-levamisole (CI=0.17) and albendazole-mebendazole (CI=0.23). For albendazole-ivermectin,moderate synergism was observed (CI=0.81) and for albendazole-levamisole a nearly additive effect was documented (CI=0.93) < em > in vivo < /em > . Five combinations (albendazole-pyrantel pamoate, mebendazole-pyrantel pamoate, levamisole-pyrantel pamoate, levamisole-ivermectin and pyrantel pamoate-ivermectin) were antagonistic < em > in vivo. < /em > Conclusion Our results strengthen the evidence that combination chemotherapy might play a rolein the treatment of < em > Trichuris < /em > infections. Albendazole-mebendazole should be studied in greater detail in preclinical studies.




Keiser, J., Tritten, L., Adelfio, R., & Vargas, M. (2012). Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo. Parasites and Vectors, 5(1). https://doi.org/10.1186/1756-3305-5-292

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free