The effect of interleukin-2 on canine peripheral nerve sheath tumours after marginal surgical excision: A double-blind randomized study

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Abstract

Background: The objective of this study was to evaluate the effect on outcomes of intraoperative recombinant human interleukin-2 injection after surgical resection of peripheral nerve sheath tumours. In this double-blind trial, 40 patients due to undergo surgical excision ( < 5 mm margins) of presumed peripheral nerve sheath tumours were randomized to receive intraoperative injection of interleukin-2 or placebo into the wound bed.Results: There were no significant differences in any variable investigated or in median survival between the two groups. The median recurrence free interval was 874 days (range 48-2141 days), The recurrence-free interval and overall survival time were significantly longer in dogs that undergone the primary surgery by a specialist-certified surgeon compared to a referring veterinarian regardless of whether additional adjunct therapy was given.Conclusion: Overall, marginal excision of peripheral nerve sheath tumours in dogs resulted in a long survival time, but adjuvant treatment with recombinant human interleukin-2 (rhIL-2) did not provide a survival advantage. © 2013 Haagsman et al.; licensee BioMed Central Ltd.

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Haagsman, A. N., Witkamp, A. C. S., Sjollema, B. E., Kik, M. J. L., & Kirpensteijn, J. (2013). The effect of interleukin-2 on canine peripheral nerve sheath tumours after marginal surgical excision: A double-blind randomized study. BMC Veterinary Research, 9. https://doi.org/10.1186/1746-6148-9-155

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