The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis

8Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

The prevalence of maternal obesity and gestational diabetes mellitus (GDM) is increasing rapidly. Probiotics supplementation have been shown to improve metabolic health in humans. In our study, we aimed to evaluate the effects of probiotics supplementation on metabolic health and pregnancy complications in pregnant women. The literature search, data extraction and quality assessment were performed, and data were synthesized in accordance with standardized guidelines. Ten randomized clinical trials with eligible data were included in our meta-analysis. For pregnant women with GDM, we found negative correlations between probiotics supplementation and fasting serum insulin (OR-2.94, 95% CI [-5.69,-0.20], p = 0.04) and homoeostasis model assessment for insulin resistance (HOMA-IR) (OR-0.65, 95%CI [-1.18,-0.11], p = 0.02). There were no significant correlations between probiotics supplementation and lipid levels in women with GDM, including total cholesterol (OR-2.72, 95%CI [-17.18, 11.74], P = 0.71), high density lipoprotein cholesterol (HDL-c) (OR-0.29, 95%CI [-3.60, 3.03], P = 0.87), low density lipoprotein cholesterol (LDL-c) (OR-0.38, 95%CI [-18.54, 17.79], P = 0.97), or triglycerides (OR-12.83, 95%CI [-36.63, 10.97], P = 0.29). For healthy pregnant women, probiotics supplementation were negatively associated with fasting serum insulin (OR-3.76, 95%CI [-4.29,-3.23], P < 0.00001) and HOMA-IR (OR-0.57, 95%CI [-1.08,-0.06], p = 0.03). However, no significant correlations were observed between probiotics supplementation and fasting plasma glucose (FPG) (OR-2.02, 95%CI [-5.56, 1.52], p = 0.26). Thus, our study revealed that probiotics supplementation during pregnancy have beneficial effects on glucose metabolism, rather than lipid metabolism among pregnant women.

Cite

CITATION STYLE

APA

Zheng, J., Feng, Q., Zheng, S., & Xiao, X. (2018). The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis. PLoS ONE, 13(5). https://doi.org/10.1371/journal.pone.0197771

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free