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Objective To evaluate the efficacy of abiraterone acetate in combination with prednisolone in Taiwanese men with metastatic castrate-resistant prostate cancer (mCRPC) who failed docetaxel-based chemotherapy. Materials and methods In this single-arm, open label study, 30 mCRPC patients with prostate specific antigen (PSA) progression after docetaxel chemotherapy were enrolled. All patients were treated with abiraterone acetate 1000 mg once daily and prednisolone 5 mg twice daily. The primary end-point was PSA response rate (defined as proportion of patients achieving a PSA decline of ≥50%). Secondary end-points were overall survival and time-to-PSA progression. Results Among 28 patients who received one or more cycles of treatment, 15 (53.6%) men achieved PSA response [95% confidence interval (CI) 33.9–72.5]. The median time-to-PSA progression was 5.5 months (95% CI 3.1–7.9). The median interval from stopping abiraterone to death was 3.4 months (95% CI 0.1–21.0), and the median overall survival was 19.2 months (95% CI 13.0–25.4). The PSA responders had better overall survival compared with PSA nonresponders, in both univariate (log rank test, p = 0.007) and multivariate (Cox regression, p = 0.001; relative risk: 0.31; 95% CI: 0.12–0.76) analysis. Both a high Gleason score (≥8) and viscera involvement did not have an unfavorable response to abiraterone treatment. Conclusion A combination of abiraterone acetate and prednisolone can improve the overall survival in Taiwanese mCRPC patients who fail prior docetaxel chemotherapy.




T., W., H.C., W., Y.C., O., S.-T., P., Y.-S., P., & Y.-H., C. (2016). The efficacy of abiraterone acetate in treating Taiwanese chemo-refractory metastatic castration-resistant prostate cancer patients. Urological Science, 27(4), 218–222. https://doi.org/10.1016/j.urols.2015.11.003 LK  - http://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=18795234&id=doi:10.1016%2Fj.urols.2015.11.003&atitle=The+efficacy+of+abiraterone+acetate+in+treating+Taiwanese+chemo-refractory+metastatic+castration-resistant+prostate+cancer+patients&stitle=Urol.+Sci.&title=Urological+Science&volume=27&issue=4&spage=218&epage=222&aulast=Wu&aufirst=Tony&auinit=T.&aufull=Wu+T.&coden=&isbn=&pages=218-222&date=2016&auinit1=T&auinitm=

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