Elastin peptides regulate proliferation, chemotaxis and protease expression. The aim of this work was to assess their influence on apoptosis. Human skin fibroblast cell death was induced using C2-ceramide in the presence or absence of elastin peptides. We show that ceramide-induced apoptosis could be blocked by elastin peptides. Using pharmacological inhibitors, we show that elastin peptide treatment leads to activation of the anti-apoptotic protein Akt that phosphorylates the pro-apoptotic protein Bad, the Foxo3a transcription factor and caspase-9. Importantly, the anti-apoptotic effects of elastin peptides were persistent in time. Our results suggest that elastin peptides could be potent cell survival factors. © 2009 Federation of European Biochemical Societies.
Cantarelli, B., Duca, L., Blanchevoye, C., Poitevin, S., Martiny, L., & Debelle, L. (2009). Elastin peptides antagonize ceramide-induced apoptosis. FEBS Letters, 583(14), 2385–2391. https://doi.org/10.1016/j.febslet.2009.06.037