Elastin peptides antagonize ceramide-induced apoptosis

Citations of this article
Mendeley users who have this article in their library.


Elastin peptides regulate proliferation, chemotaxis and protease expression. The aim of this work was to assess their influence on apoptosis. Human skin fibroblast cell death was induced using C2-ceramide in the presence or absence of elastin peptides. We show that ceramide-induced apoptosis could be blocked by elastin peptides. Using pharmacological inhibitors, we show that elastin peptide treatment leads to activation of the anti-apoptotic protein Akt that phosphorylates the pro-apoptotic protein Bad, the Foxo3a transcription factor and caspase-9. Importantly, the anti-apoptotic effects of elastin peptides were persistent in time. Our results suggest that elastin peptides could be potent cell survival factors. © 2009 Federation of European Biochemical Societies.




Cantarelli, B., Duca, L., Blanchevoye, C., Poitevin, S., Martiny, L., & Debelle, L. (2009). Elastin peptides antagonize ceramide-induced apoptosis. FEBS Letters, 583(14), 2385–2391. https://doi.org/10.1016/j.febslet.2009.06.037

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free