Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer

Citations of this article
Mendeley users who have this article in their library.


There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone-sensitive tissues, such as the cervix. We studied the association of CYP1A1 M1 ( rs4646903 ) and COMT ( rs4680 ) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls. The CYP1A1 TT genotype was associated with a lower risk for c-cancer (OR = 0.39, p=0.002 ). The allele C of CYP1A1 was a risk for c-cancer (OR = 2.29, p=0.002 ). Women with COMT LL genotype had a higher risk of developing c-cancer (OR = 4.83, p<0.001 ). For the interaction of the CYP1A1 & COMT , we observed that TC&HL genotypes had a greater risk for c-cancer (OR = 6.07, p=0.006 ) and TT&HL genotypes had a protection effect (OR = 0.24, p<0.001 ). The CYP1A1 TT and COMT LL genotypes had higher estradiol levels in c-cancer ( p<0.001 and p=0.037 , resp.). C-cancer is associated with less production of 2-methoxy-estradiol resultant of functional polymorphisms of CYP1A1 and COMT , separately. CYP1A1 and COMT work in a metabolic sequence and their interaction could lead to an alternative pathway of estrogen metabolism with production of 16-OH-estrone that is more proliferative.




Matos, A., Castelão, C., Pereira Da Silva, A., Alho, I., Bicho, M., Medeiros, R., & Clara Bicho, M. (2016). Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer. Oxidative Medicine and Cellular Longevity, 2016. https://doi.org/10.1155/2016/2769804

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free