Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity

Abstract

Chronic elevation of the sympathetic nervous system has been identified as a major con- tributor to the complex pathophysiology of hypertension, states of volume overload - such as heart failure - and progressive kidney disease. It is also a strong determinant for clin- ical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option. © 2012 Vink and Blankestijn.