Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload - such as heart failure - and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.
Vink, E. E., & Blankestijn, P. J. (2012). Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. Frontiers in Physiology, 3 FEB. https://doi.org/10.3389/fphys.2012.00029