Exercise and vagal reflex in long QT syndrome type 1

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Mark Twain's view on exercise would serve very well for many patients with long QT syndrome type 1 (LQT1)—the most common form of the long QT syndrome (LQTS). LQT1 is caused by loss-of-function mutations in KCNQ1, which encode the adrenergic-sensitive IKs channel (2). LQT1 patients usually develop life-threatening arrhythmias during increased sympathetic activity situations (i.e., physical exercise, emotional or physical stress, especially swimming). Recent studies have shed some light on adverse effects of exercise and increased adrenergic activity on LQT1 patients




Nademanee, K. (2012, December 18). Exercise and vagal reflex in long QT syndrome type 1. Journal of the American College of Cardiology. Elsevier USA. https://doi.org/10.1016/j.jacc.2012.08.1007

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