The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C-H functionalization of sulfuror nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium. © 2012 Martin et al; licensee Beilstein-Institut.
Martin, A. R., Chartoire, A., Slawin, A. M. Z., & Nolan, S. P. (2012). Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles. Beilstein Journal of Organic Chemistry, 8, 1637–1643. https://doi.org/10.3762/bjoc.8.187