In this retrospective analysis, data pooled from two Phase III/IV open-label Asian studies were used to quantify the additional blood pressure efficacy achieved when titrating amlodipine from 5 mg to 10 mg in mild/moderate hypertensive patients, and compared to data pooled from three Western studies. The primary efficacy end point was the change from base-line in sitting systolic blood pressure (SBP) and diastolic blood pressure (DBP) to the specified time point (4-8 weeks, depending on the trial). For the Asian analysis (n=174), both mean SBP and DBP were significantly decreased at the final visit (SBP-13.3 mmHg, 95% confidence interval [CI]-15.5 to-11.0; DBP-9.2 mmHg, 95% CI-10.6 to -7.8; both P<0.0001). These results were similar to the Western analysis (n=369; SBP-11.5 mmHg, 95% CI-13.1 to-10.0; DBP-6.3, 95% CI-7.1 to-5.5; both P<0.0001). In summary, titration of amlodipine from 5 mg to 10 mg significantly decreased both SBP and DBP in Asian patients with mild-to-moderate hypertension. © 2013 Kario et al.
CITATION STYLE
Kario, K., Robbins, J., & Jeffers, B. W. (2013). Titration of amlodipine to higher doses: A comparison of Asian and Western experience. Vascular Health and Risk Management, 9(1), 695–701. https://doi.org/10.2147/VHRM.S50077
Mendeley helps you to discover research relevant for your work.