Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. Objective: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. Method: CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend® portable analyzer were compared to those tested by a reference device (SYNCHRON LX® 20). Results: The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. Conclusions: These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.
CITATION STYLE
de Almeida, S. M., Marquie-Beck, J., Bhatt, A., Letendre, S., McCutchan, J. A., Ellis, R. J., … Kao, C. (2014). Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - Method-comparison evaluations. Arquivos de Neuro-Psiquiatria, 72(7), 500–505. https://doi.org/10.1590/0004-282X20140076
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