Seven Theses on the Biology of Music and Language

Abstract

Objective: The aim of the present study was to evaluate the efficacy of minimal hCG suplementation in the luteal phase when using a Bolus of GnRH to trigger the ovulation. Study design: A retrospective studywhere three groups of patients were compared: 54 patients which ovulation was induced with hCG (hCG Group), 98 patients which ovulation was induced with a bolus of GnRH agonist and received three doses of 500 IU hCG the days 1.4 and 7 after oocyte retrieval (GnRH3 Group), and 79 patients which ovulation was induced with a bolus of GnRH agonist and received two doses of 500 IU hCG the days 1 and 5 after oocyteretrieval (GnRH2 Group). Progesterone and oestradiol were also administered in all groups. We employed analysis of ANOVA, chi-squaretest or logistic regression to performed the statistical analysis. Results: There were no significant differences between the three studied groups in the clinical pregnancy rate (hCG =54.9%, GnRH 3 =58.1%, GnRH 2 =58.6%), implantation rate (hCG =49.1 %, GnRH 3 =43.8%, GnRH 2 =43. 1%), miscarriage rate (hCG =1 7.9%, GnRH 3 = 14.8%, GnRH 2 =17.1%), or in the distribution of progesterone levels in the luteal phase. No patients in any group developed OHSS. Conclusions: Minimal doses of 500 UI hCG after a bolus of GnRH to trigger ov u lation seem to be sufficient to maintain corpus luteum function and pregnancy rates.