The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives. The novel derivatives are useful as bright blue-shifted CTZ derivatives, which can be used as an alternative to hitherto reported compound DeepBlueC™.
CITATION STYLE
Nishihara, R., Citterio, D., & Suzuki, K. (2016). Synthetic bioluminescent coelenterazine derivatives. In Methods in Molecular Biology (Vol. 1461, pp. 19–31). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3813-1_2
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