Neuroprotective potential of withania somnifera (ashwagandha) in neurological conditions

Abstract

Withania somnifera, commonly known as Ashwagandha, is a herb used in the Indian Ayurvedic medical system for centuries for its health benefits in wide range of conditions. It has been documented to enhance the functions of the nervous system and improves cognition. Medicinal properties of Withania somnifera are primarily attributed to the presence of active constituents known as withanolides. The multimodal beneficial effects of WS and its constituents stem from its property to act as an anti-oxidant, anti-inflammatory, anti-cancer, hemopoietic and rejuvenating agent. WS has been shown to have beneficial role in many neurological conditions that include Alzheimer's disease, Parkinson's disease, Huntington's disease, anxiety disorders, cerebral ischemia. However, the mechanisms involved in the beneficial effects of WS have not been well understood. The article provides information on the mechanisms involved in neuroprotective ability of WS in preventing various neurodegenerative conditions.