Assessment of hemodynamic responses in cerebral ischemic rats using near infrared spectroscopy

Abstract

Ischemic stroke is a high prevailing and disease in industrialized countries. A valid animal model is essential to develop an extensive research. Among various models, middle cerebral artery occlusion (MCAO) is one of the common used ischemic stroke animal models. In this study, we evaluate the absorption coefficient, reduced scattering coefficient and hemodynamic responses using near infrared spectroscopy (NIRS). The correlation between NIRS signals and the brain infarction volume was measured from histochemical stain. Through the well correlation about reduced scattering coefficient, NIRS can be an effective tool to evaluate ischemic stroke.