The influence of inhibition of uptake2 and of O-methylation on beta-adrenoceptor-mediated responses of guinea-pig trachea and rat uterus to some catecholamines was compared. The responses were more markedly enhanced by inhibition of O-methylation (by U-0521) than by inhibition of uptake2 (by hydrocortisone). The ranking order for the degree of super-sensitivity caused by either U-0521 or hydrocortisone was different in the two tissues, suggesting differences between the O-methylating systems of those tissues. In experiments with 3H-isoprenaline metabolism, hydrocortisone had a weak inhibitory effect on O-methylation in both tissues.
CITATION STYLE
Proença, J., Paiva, M. Q., & Guimarães, S. (1990). Supersensitivity to catecholamines after inhibition of extraneuronal uptake (uptake2) or O-methylation. Journal of Neural Transmission. Supplementum, 32, 463–467. https://doi.org/10.1007/978-3-7091-9113-2_63
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