Characterization of two novel polysaccharides having immunological activities from the root of panax ginseng.

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Abstract

Two acidic polysaccharides, called ginsenan-S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. MEYER. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6×104 and 1.0×105, respectively. Ginsenan S-IA is composed of L-arabinose : D-galactose : D-galacturonic acid in the molar ratio of 8 : 8 : 1, and ginsenan S-IIA is composed of L-arabinose : D-galactose : D-glucose : D-galacturonic acid in the molar ratio of 15 : 10 : 2 : 5, in addition to small amounts of O-acetyl groups. About a half (ginsenan S-IA) and about a quarter (ginsenan S-IIA) of the hexuronic acid residues exist as methyl esters. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and periodate oxidation studies indicated that their structural features include mainly α-1, 5-linked L-arabino-β-3, 6-branched D-galactan type structural units. Both polysaccharides showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and pronounced anti-complementary activity. These substances are the first examples having a relatively high content of both α-3, 5-branched L-arabinose and β-1, 4-linked D-galactose units among the acidic arabinogalactans with activities on phagocytosis and anti-complement. © 1993, The Pharmaceutical Society of Japan. All rights reserved.

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Tomoda, M., Hirabayashi, K., Shimizu, N., Gonda, R., Ōhara, N., & Takada, K. (1993). Characterization of two novel polysaccharides having immunological activities from the root of panax ginseng. Biological and Pharmaceutical Bulletin, 16(11), 1087–1090. https://doi.org/10.1248/bpb.16.1087

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