Resolving for changes in concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy has generally been based on the assumption that optical scattering and pathlength remain constant. We have used a novel hybrid optical spectrometer that combines multi-distance frequency and broadband systems to investigate the changes in scattering and pathlength during a Valsalva manoeuvre in 8 adult volunteers. Results show a significant increase in the reduced scattering coefficient of 17% at 790nm and 850nm in 4 volunteers during the peak of the Valsalva. However, these scattering changes do not appear to significantly affect the differential pathlength factor and the tissue haemoglobin concentration measurements. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Gao, L., Elwell, C. E., Kohl-Bareis, M., Gramer, M., Cooper, C. E., Leung, T. S., & Tachtsidis, I. (2011). Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva manoeuvre. In Advances in Experimental Medicine and Biology (Vol. 701, pp. 15–20). Springer New York LLC. https://doi.org/10.1007/978-1-4419-7756-4_3
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