Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetics for Biomedical Application

Abstract

Iron oxideIron oxidenanoparticles have been widely used in many important fields due to excellent nanoscale physical properties such as magnetism/superparamagnetism, and they are usually assumed biological inert. However, in the last few years, iron oxide nanoparticles were surprisingly found with intrinsic enzyme-like activitiesEnzyme-like activitiesand are now widely regarded as novel enzyme mimetics. A specified term, “Nanozyme”, has been coined to define the new property for intrinsic enzymatic activities of nanomaterials. Since then, iron oxideIron oxidenanoparticles have been used as nanozyme to facilitate their biomedical applicationsBiomedical applications. In this review, we will systematically introduce the enzymatic features of iron oxide nanozyme (IONzyme) and summarize the extended novel applications based on the intrinsic enzyme-like activitiesEnzyme-like activities.