New insight puts CRAF in sight as a therapeutic target

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Abstract

By selectively depleting components of the RAF-MEK-ERK pathway in transgenic mice, it is now shown in 2 studies that CRAF is critical for signaling to MEK downstream of oncogenic Kras and that BRAF is not required. © 2011 American Association for Cancer Research.

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Rebocho, A. P., & Marais, R. (2011). New insight puts CRAF in sight as a therapeutic target. Cancer Discovery, 1(2), 98–99. https://doi.org/10.1158/2159-8290.CD-11-0118

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