SpliceDetector: A software for detection of alternative splicing events in human and model organisms directly from transcript IDs

8Citations
Citations of this article
73Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In eukaryotes, different combinations of exons lead to multiple transcripts with various functions in protein level, in a process called alternative splicing (AS). Unfolding the complexity of functional genomics through genome-wide profiling of AS and determining the altered ultimate products provide new insights for better understanding of many biological processes, disease progress as well as drug development programs to target harmful splicing variants. The current available tools of alternative splicing work with raw data and include heavy computation. In particular, there is a shortcoming in tools to discover AS events directly from transcripts. Here, we developed a Windows-based user-friendly tool for identifying AS events from transcripts without the need to any advanced computer skill or database download. Meanwhile, due to online working mode, our application employs the updated SpliceGraphs without the need to any resource updating. First, SpliceGraph forms based on the frequency of active splice sites in pre-mRNA. Then, the presented approach compares query transcript exons to SpliceGraph exons. The tool provides the possibility of statistical analysis of AS events as well as AS visualization compared to SpliceGraph. The developed application works for transcript sets in human and model organisms.

Cite

CITATION STYLE

APA

Baharlou Houreh, M., Ghorbani Kalkhajeh, P., Niazi, A., Ebrahimi, F., & Ebrahimie, E. (2018). SpliceDetector: A software for detection of alternative splicing events in human and model organisms directly from transcript IDs. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-23245-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free