Ex vivo localization and permeation of cisplatin from novel topical formulations through excised pig, goat, and mice skin and in vitro characterization for effective management of skin-cited malignancies

Abstract

Context: It would be advantageous to administer cisplatin topically for treatment of cutaneous malignancies. Objectives: Present work focuses on ex vivo and in vitro characterization of proultraflexible topical formulations. Materials and methods: Permeation of cisplatin through the excised pig, goat, and mice skin was quantitatively determined. Results: Data indicate that protransfersome carbopol gel (pcg) formulation clearly delayed drug permeation through skin. Permeation of cisplatin from protransfersome system (ps) formulation was enhanced by approximately 1.5 fold compared with pcg for pig and goat skin. Discussion: Localization of drug from pcg was higher and showed less permeation. Conclusion: Cisplatin-loaded pcg formulation is better to treat cutaneous malignancies.