GREEN SYNTHESIS OF 1,4-DISUBSTITUTED 1,2,3-TRIAZOLE ACETAMIDE DERIVATIVES BY UTILIZING THE CLICK CHEMISTRY APPROACH

Abstract

A library of 1,4-disubstituted 1,2,3-triazole acetamide derivatives has been designed and synthesized via a click chemistry approach by using thiazole acetamide azide and acetylene derivative of quinoxaline is described. All the final compounds obtained in an excellent yield (>90%) and were well characterized by analytical spectroscopic methods like1 H NMR,13 C NMR, and Mass spectroscopy. The work reported herewith demonstrates the importance of green chemical synthesis using alternative solvents (water & n-butanol) in experiments to reduce the environmental impact of chemical processes.