Immune response of infants and preschoold children to typhoid vaccine given intradermally or subcutaneously

Abstract

In developing countries typhoid fever is common not only in adults and children of school age but also in infants and preschool children, in whom the rate of complications and the case fatality rate may be as high as in older children. Children should therefore be immunised against typhoid fever as early as possible. The immunogenic and protective efficacies of the currenly available heat inactivated typhoid vaccine have been investigated only in schoolchildren and adults. We therefore measured its immunogenicity in infants and preschool children.