To regulate the switch effect induced by NH anion substitution at the H8 site of the guanine-cytosine (GC) watson-crick pair and investigate the actual state in the solution, 1-9 water molecules attached GNH-C derivatives are probed in the present paper. Results show that the switch effect, i.e., deformation effect of hydrogen bonding between GNH- and C pair reduces step-wise as the number of discrete water molecules around the NH - group increases. Thus one can control the switch action of G NH-C by regulating the number of water molecules around the NH - group. © Springer-Verlag Berlin Heidelberg 2007.
CITATION STYLE
Ai, H., Peng, X., Li, Y., & Zhang, C. (2007). Regulative effect of water molecules on the switches of guanine-cytosine (GC) watson-crick pair. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4488 LNCS, pp. 327–330). Springer Verlag. https://doi.org/10.1007/978-3-540-72586-2_46
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