Lipase-catalyzed dynamic kinetic resolution of chiral amines: Use of palladium as the racemization catalyst

Abstract

The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75-77% (ee = 99%).