Chemical constituents and antimicrobial activity of branches and leaves of Cordia insignis (Boraginaceae)

Abstract

Phytochemical investigation of the branches and leaves of the species Cordia insignis led to the isolation and identification of β-sitosterol (1), stigmasterol (2), campesterol (3), β-sitosterol 3-O-β-D-glucopyranoside (4), stigmasterol 3-O-β-D-glucopyranoside (5), scoparone (6), α-amyrin (7), β-amyrin (8), methyl caffeate (9), allantoin (10), scopoletin (11), caffeic acid (12), methyl rosmarinate (13). These substances had their structures determined by analysis of their 1D and 2D NMR and GC-MS spectra and by comparison with data reported in the literature. The hydroethanolic extracts of the branches and leaves and their respective fractions were submitted to antibacterial and antifungal evaluation. The extracts and fractions showed good antifungal activity but did not present antibacterial activity. This study is the first work with C. insignis.