Three-dimensional (3D) and drug-eluting nanofiber coating for prosthetic implants

Abstract

Failure of osseointegration and implant infection are the two main causes of implant failure and loosening. There is an urgent need for orthopedic implants that promote rapid osseointegration and prevent infection, particularly when placed in bone compromised by disease or physiology of the patients. This chapter reviews current and potential future use of biologic and drug-eluting coatings for orthopedic implants to facilitate osseointegration and prevent implant infection. The potential application of porous and drug-eluting coaxial nanofiber as a means of alternative implant surface coating was discussed.