A highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds

Abstract

(Chemical Equation Presented) Unprecedented activity: Catalysts derived from Pd and bulky dialkylphosphinobiaryl ligands are shown to be highly stable and active in Suzuki-Miyaura reactions of heteroaryl halides and heteroaryl boronic acids/esters (e.g., 3-or 4-pyridine, indole, and N-protected pyrrole derivatives). Furthermore, this catalyst system is not inhibited by the presence of highly basic aminopyridines or aminopyrimidines. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.