A gene expression map of human chromosome 21 orthologues in the mouse

99Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The DNA sequence of human chromosome 21 (HSA21) has opened the route for a systematic molecular characterization of all of its genes. Trisomy 21 is associated with Down's syndrome, the most common genetic cause of mental retardation in humans. The phenotype includes various organ dysmorphies, stereotypic craniofacial anomalies and brain malformations. Molecular analysis of congenital aneuploidies poses a particular challenge because the aneuploid region contains many protein-coding genes whose function is unknown. One essential step towards understanding their function is to analyse mRNA expression patterns at key stages of organism development. Seminal works in flies, frogs and mice showed that genes whose expression is restricted spatially and/or temporally are often linked with specific ontogenic processes. Here we describe expression profiles of mouse orthologues to HSA21 genes by a combination of largescale mRNA in situ hybridization at critical stages of embryonic and brain development and in silico (computed) mining of expressed sequence tags. This chromosome-scale expression annotation associates many of the genes tested with a potential biological role and suggests candidates for the pathogenesis of Down's syndrome.

Cite

CITATION STYLE

APA

Gitton, Y., Dahmane, N., Baik, S., Ruiz i Altaba, A., Neidhardt, L., Scholze, M., … Yaspo, M. L. (2002). A gene expression map of human chromosome 21 orthologues in the mouse. Nature, 420(6915), 586–590. https://doi.org/10.1038/nature01270

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free