The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy

Abstract

Background: Inflammation is believed to play a role in preeclampsia. Leukocytes increase due to inflammatory response. Endothelial damage in preeclampsia induces platelet aggregation, triggers platelet consumption, and decreases platelet. Therefore, preeclampsia could alter the platelet-white blood cell ratio, which can be used as a marker for preeclampsia. This study examines the difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy. Methods: This study used the medical records of pregnant women in Dr. Kariadi General Hospital Semarang from 2019 to 2020. Samples were collected using a consecutive sampling method. Data were analyzed using an independent t-test and Mann-Whitney. Results: There was a significant difference in platelet count (p=0.011) and leukocyte count (p=0.018) between severe preeclampsia and normotensive pregnancy. Therefore, a difference (p<0.01) inplatelet-white blood cell ratio between severe preeclampsia and normotensive pregnancy was observed. Conclusion: Platelet-white blood cell ratio in severe preeclampsia is 0.7 times lower than in normotensive pregnancy.