Template-assembled synthetic G-quartets (TASQs)

Abstract

An unusual quartet: Four guanine residues have been efficiently "clicked" onto a cavitand to create a lipophilic template-assembled synthetic G-quartet (TASQ) structure in CDCl3. The TASQ manifests unusual cation-free structural integrity and stability. This cation-free basket, as well as corresponding potential cation-bound quartets and cation-induced quadruplexes may find applications in health therapies. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.