Gas chromatographic-mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injection

30Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

A method is described for the simultaneous determination of two short-chained amides, acrylamide and acetamide (classified by the International Agency for Research on Cancer as probable and possible human carcinogens, respectively), in total particulate matter using gas chromatography-on-column injection and mass spectrometric detection. Sample preparation is kept to a minimum, and the proposed analytical procedure proves to be fast, sensitive, and precise. Validation studies show good linearity with a regression coefficient of r2 =1.000 for both compounds. Quantitation limits are 32 ng/mL for acrylamide and 70 ng/mL for acetamide. In the particulate phase of mainstream smoke from the University of Kentucky Reference Cigarette 2R4F, 2.3 μg/cig acrylamide and 4.7 μg/cig acetamide are found; no acetamide and only .0074 μg/cig acrylamide is found in the gas phase. Possible mechanisms of formation in cigarette smoke are discussed.

Cite

CITATION STYLE

APA

Diekmann, J., Wittig, A., & Stabbert, R. (2008). Gas chromatographic-mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injection. Journal of Chromatographic Science, 46(7), 659–663. https://doi.org/10.1093/chromsci/46.7.659

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free