To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.
CITATION STYLE
Araškov, J. B., Nikolić, M., Armaković, S., Armaković, S., Rodić, M., Višnjevac, A., … Filipović, N. R. (2021). Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres. Journal of Molecular Structure, 1240. https://doi.org/10.1016/j.molstruc.2021.130512
Mendeley helps you to discover research relevant for your work.