Analytical expression for the NO concentration profile following NONOate decomposition in the presence of oxygen

Abstract

We have derived an analytical expression for the time dependent NO concentration from NONOate donors in the presence of oxygen for the process of NO release from NO donors following autoxidation. This analytical solution incorporates the kinetics of the releases with the autoxidation and is used to fit the simulated NO concentration profile to the experimental data. This allows one to determine the NO release rate constant, k1, the NO release stoichiometric coefficient, vNO, and the NO autoxidation reaction rate constant, k2. This analytical solution also allows us to predict the real NO concentration released from NO donors under aerobic conditions, while vNO is reportedly two under aerobic conditions, it falls to lower values in the presence of oxygen.